Clinical Observation of Danshen Chuanxiongqin Injection Combined with Flunarizine Hydrochloride in the Prevention of Benign Paroxysmal Positional Vertigo and Lower Extremity Deep Venous Thrombosis in Post-operative Long-term Bedridden Patients with Lower Limb Fractures / 中国药房

OBJECTIVE:To observe therapeutic efficacy and safety of Danshen chuanxiongqin injection combined with flunari-zine hydrochloride in the benign prevention and treatment of paroxysmal positional vertigo (BPPV) and lower extremity deep ve-nous thrombosis (DVT) in post-operative long-term bedridden patients with lower limb fractures. METHODS:300 post-operative long-term bedridden patients with lower limb fractures were selected and randomly divided into observation group and control group,with 150 cases in each group. Control group was given Flunarizine hydrochloride capsules orally 10 mg,qd;observation group was additionally given Danshen chuanxiongqin injection 10 ml+5% Glucose injection 250 ml,ivgtt,qd. The incidence of BPPV and DVT were observed in 2 groups after intervention,and the circumference of lower limb,blood coagulation indexes, blood rheology indexes and inflammatory factor were observed before and after intervention,and the incidence of ADR was com-pared. RESULTS:The incidence of BPPV and DVT in observation group were 18.0% and 16.7%,which were significantly lower than in control group(48.7% and 52.7%),with statistical significance(P0.05). CONCLUSIONS:Danshen chuanxiongqin injection combined with flunarizine hydrochloride is effective in the prevention of BPPV and DVT in long-term bed-ridden patients with lower limb fractures,with low incidence of ADR.

Dura mater substitutes / 中国组织工程研究

Cerebral dura mater substitutes for dural repair are essential to maintain anatomical integrity and cerebral protection. Currently, there are three substitutes of cerebral dura mater including xenograft (bovine pericardium), allograft (cadaver cerebral dura mater) and synthesized material (expended polytetrafluoroethylene). Each material has their specific advantages, accompanied by some drawbacks. For example, autologous membrane material has limited sources and worse intensity than natural dura mater, and may induce secondary trauma; allogenous membrane can cause viral infection; xenogenous membrane has residual toxicity after glutaral processing; gelatin sponge has rapid degradation, but its intensity is bad and unable to suture. The synthesized material based on allogenous and xenogenous materials may be developed by the combination of their specific advantages.